Neuronal diseases: small heat shock proteins calm your nerves

Ming Der Perng; Roy A Quinlan

doi:10.1016/j.cub.2004.07.047

Neuronal diseases: small heat shock proteins calm your nerves

Curr Biol. 2004 Aug 10;14(15):R625-6. doi: 10.1016/j.cub.2004.07.047.

Authors

Ming Der Perng¹, Roy A Quinlan

Affiliation

¹ School of Biological and Biomedical Science, South Road Science Site, The University, Durham DH1 3LE, UK.

PMID: 15296780
DOI: 10.1016/j.cub.2004.07.047

Abstract

Mutations in HSPB1 and HSPB8, members of the small heat shock protein family, have recently been shown to cause some distal motor neuropathies. Their function in motor neurones is now under scrutiny.

Publication types

Review

MeSH terms

Biological Transport / physiology
HSP27 Heat-Shock Proteins
Heat-Shock Proteins / genetics*
Heat-Shock Proteins / metabolism
Hereditary Sensory and Motor Neuropathy / genetics*
Hereditary Sensory and Motor Neuropathy / physiopathology
Humans
Intermediate Filaments / metabolism
Intermediate Filaments / physiology
Models, Biological
Molecular Chaperones
Motor Neurons / metabolism*
Mutation / genetics*
Neoplasm Proteins / genetics*
Neoplasm Proteins / metabolism
Protein Serine-Threonine Kinases / genetics*
Protein Serine-Threonine Kinases / metabolism

Substances

HSP27 Heat-Shock Proteins
HSPB1 protein, human
HSPB8 protein, human
Heat-Shock Proteins
Molecular Chaperones
Neoplasm Proteins
Protein Serine-Threonine Kinases