Abstract
An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002).
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age of Onset
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Aged
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Aged, 80 and over
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Ethnicity / genetics
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Female
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Genetic Predisposition to Disease
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Great Lakes Region / epidemiology
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Haplotypes / genetics
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Humans
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Intracellular Signaling Peptides and Proteins
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Linkage Disequilibrium
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Male
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Middle Aged
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Oncogene Proteins / genetics
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Oncogene Proteins / physiology*
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Parkinson Disease / epidemiology
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Parkinson Disease / genetics*
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Polymorphism, Single Nucleotide*
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Prospective Studies
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Protein Deglycase DJ-1
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Receptors, Androgen / metabolism
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Sex Characteristics*
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Siblings
Substances
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Intracellular Signaling Peptides and Proteins
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Oncogene Proteins
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Receptors, Androgen
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PARK7 protein, human
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Protein Deglycase DJ-1