Abstract
Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Colorectal Neoplasms / enzymology
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / mortality
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Colorectal Neoplasms / pathology
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Cyclooxygenase 1
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Cyclooxygenase 2
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DNA Primers
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Humans
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Intestinal Mucosa / enzymology
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Isoenzymes / genetics*
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Membrane Proteins
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Neoplasm Staging
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Polymerase Chain Reaction / methods
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Prostaglandin-Endoperoxide Synthases / genetics*
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RNA, Neoplasm / genetics*
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Reference Values
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Ribotyping / methods
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Survival Analysis
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Time Factors
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Transcription, Genetic / genetics
Substances
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DNA Primers
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Isoenzymes
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Membrane Proteins
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RNA, Neoplasm
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Cyclooxygenase 1
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Cyclooxygenase 2
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PTGS1 protein, human
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases