Abstract
We performed mRNA in situ hybridization for TNF-alpha and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Brain / cytology
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Brain / immunology*
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Brain / microbiology
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Gene Expression Regulation
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Humans
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In Situ Hybridization
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Interleukin-1 / genetics
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Interleukin-1 / metabolism*
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Meningitis, Pneumococcal / immunology*
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Rats
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Rats, Sprague-Dawley
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Streptococcal Infections / immunology*
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Interleukin-1
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Tumor Necrosis Factor-alpha