Abstract
Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle / physiology
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Cyclin-Dependent Kinases / metabolism
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Drug Design
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Evolution, Molecular
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F-Box Proteins / classification
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F-Box Proteins / genetics
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F-Box Proteins / metabolism*
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Humans
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Models, Molecular
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Protein Structure, Tertiary
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SKP Cullin F-Box Protein Ligases / chemistry
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SKP Cullin F-Box Protein Ligases / genetics
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SKP Cullin F-Box Protein Ligases / metabolism*
Substances
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F-Box Proteins
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SKP Cullin F-Box Protein Ligases
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Cyclin-Dependent Kinases