IL-23 and IFN-gamma deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy

Silvia Lee; Martyn A H French; Patricia Price

doi:10.1097/00002030-200406180-00014

IL-23 and IFN-gamma deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy

AIDS. 2004 Jun 18;18(9):1337-40. doi: 10.1097/00002030-200406180-00014.

Authors

Silvia Lee¹, Martyn A H French, Patricia Price

Affiliation

¹ Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Western Australia.

PMID: 15362668
DOI: 10.1097/00002030-200406180-00014

Abstract

The pathogenesis of HIV infection and the susceptibility to opportunistic infections has been associated with poor type 1 cytokine production. In severely immunodeficient HIV patients who achieved increased CD4 T-cell counts on longterm highly active antiretroviral therapy, we observed reduced expression of IL-23p19 and IFN-gamma messenger RNA. Impaired IL-23-induced IFN-gamma production by memory T cells might thus contribute to opportunistic infections in a minority of patients with substantial CD4 T-cell recovery.

MeSH terms

Adult
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Case-Control Studies
HIV Infections / drug therapy
HIV Infections / immunology*
Humans
Interferon-gamma / deficiency*
Interferon-gamma / genetics
Interleukin-23
Interleukin-23 Subunit p19
Interleukins / deficiency*
Interleukins / genetics
Lymphocytes / immunology
Male
RNA, Messenger / analysis
Reverse Transcriptase Inhibitors / therapeutic use

Substances

IL23A protein, human
Interleukin-23
Interleukin-23 Subunit p19
Interleukins
RNA, Messenger
Reverse Transcriptase Inhibitors
Interferon-gamma