No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population

Yanbin Jia; Xin Yu; Boyu Zhang; Yanbo Yuan; Qi Xu; Yucun Shen; Yan Shen

doi:10.1016/j.eurpsy.2004.04.017

No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population

Eur Psychiatry. 2004 Sep;19(6):374-6. doi: 10.1016/j.eurpsy.2004.04.017.

Authors

Yanbin Jia¹, Xin Yu, Boyu Zhang, Yanbo Yuan, Qi Xu, Yucun Shen, Yan Shen

Affiliation

¹ National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China.

PMID: 15363478
DOI: 10.1016/j.eurpsy.2004.04.017

Abstract

We genotyped six SNPs in the genes of p450 family among paranoid schizophrenics and normal controls. All subjects are unrelated Han Chinese. Three showed polymorphic, and no significant differences in allele or genotype frequencies were detected between patients and controls. Thus we obtained no evidence for the involvement of the polymorphisms in paranoid schizophrenia in the population investigated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Aryl Hydrocarbon Hydroxylases / genetics*
Cytochrome P-450 CYP1A2 / genetics*
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / genetics*
DNA Primers / genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide / genetics
Schizophrenia, Paranoid / ethnology*
Schizophrenia, Paranoid / genetics*

Substances

DNA Primers
Cytochrome P-450 Enzyme System
CYP2C9 protein, human
Cytochrome P-450 CYP2C9
Aryl Hydrocarbon Hydroxylases
CYP3A protein, human
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP3A