Abstract
We investigated on colon cancer cells the effect of geraniol on thymidylate synthase and thymidine kinase expression, two enzymes related to 5-fluorouracil cytotoxicity. The anti-tumoral efficacy of geraniol and 5-fluorouracil were also evaluated on TC-118 human tumors transplanted in Swiss nu/nu mice. Geraniol (150 microM) but not 5-fluorouracil caused a 2-fold reduction of thymidylate synthase and thymidine kinase expression in cancer cells. In nude mice, the combined administration of 5-fluorouracil (20 mg/kg) and geraniol (150 mg/kg) caused a 53% reduction of the tumor volume, whereas a 26% reduction was obtained with geraniol alone, 5-fluorouracil alone showed no effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclic Monoterpenes
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Animals
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Antimetabolites, Antineoplastic / therapeutic use*
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / enzymology
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Colonic Neoplasms / pathology
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DNA / metabolism*
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Drug Therapy, Combination
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Female
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Fluorouracil / therapeutic use*
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Humans
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Mice
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Mice, Nude
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Oils, Volatile*
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Plant Oils
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Terpenes / administration & dosage*
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Thymidine Kinase / genetics
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Thymidine Kinase / metabolism
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Thymidylate Synthase / genetics
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Thymidylate Synthase / metabolism
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Transplantation, Heterologous
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Tumor Cells, Cultured
Substances
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Acyclic Monoterpenes
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Antimetabolites, Antineoplastic
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Oils, Volatile
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Plant Oils
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RNA, Messenger
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Terpenes
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DNA
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Thymidylate Synthase
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Thymidine Kinase
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geraniol
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Fluorouracil