Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples

Am J Med Genet B Neuropsychiatr Genet. 2004 Nov 15;131B(1):6-9. doi: 10.1002/ajmg.b.30083.

Abstract

The present study investigated polymorphisms of the NOTCH 4 gene in two independent samples from India and USA, consisting of patients with schizophrenia and their parents (n = 182, and n = 148 'trios,' respectively). Five DNA markers, namely (GAAG)(n), (TAA)(n), SNP1, SNP2, and (CTG)(n) were evaluated. Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Base Sequence
  • Family Health
  • Female
  • Genotype
  • Haplotypes
  • Humans
  • India
  • Linkage Disequilibrium
  • Male
  • Nuclear Family
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Proto-Oncogene Proteins / genetics*
  • Receptor, Notch4
  • Receptors, Cell Surface / genetics*
  • Receptors, Notch
  • Schizophrenia / genetics*
  • Trinucleotide Repeats / genetics
  • United States

Substances

  • NOTCH4 protein, human
  • Proto-Oncogene Proteins
  • Receptor, Notch4
  • Receptors, Cell Surface
  • Receptors, Notch