Abstract
The authors analyzed the female: male (F:M) ratio according to the HLA-DRB1-DQB1 genotype in a cohort of multiple sclerosis (MS) patients from Sardinia, where the disease is associated with DR3 and DR4. In the whole cohort of 1,097 patients, F:M ratio was 2.24; however, it was 2.88 in DR3/DR3 and 2.52 in DR3/DRX (X#DR3 and DR4) individuals. Parental transmission of DR3 and DR4, assessed in a set of 565 case-parent triads, showed evidence of paternal inheritance of DR3 in affected women, thus explaining the excess of females in the DR3 category.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Chromosome Segregation*
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Cohort Studies
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Fathers
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Female
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Gene Frequency
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Genes, MHC Class II*
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Genetic Predisposition to Disease
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HLA-DQ Antigens / genetics
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics
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HLA-DR3 Antigen / genetics*
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HLA-DR4 Antigen / genetics
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HLA-DRB1 Chains
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Haplotypes / genetics
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Humans
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Italy / epidemiology
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Logistic Models
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Male
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Multiple Sclerosis / epidemiology
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / immunology
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Sex Distribution
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Siblings
Substances
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DR3 Antigen
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HLA-DR4 Antigen
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HLA-DRB1 Chains