Abstract
The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
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Adult
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Alleles
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Amino Acid Substitution
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Anticonvulsants / pharmacology*
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Anticonvulsants / therapeutic use
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Austria
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Drug Resistance, Multiple / genetics*
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Epilepsy, Temporal Lobe / drug therapy
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Epilepsy, Temporal Lobe / genetics*
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Exons / genetics
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Female
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Genotype
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Haplotypes / genetics
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Hippocampus / pathology
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Mutation, Missense
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Polymorphism, Genetic
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Polymorphism, Single Nucleotide
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Sclerosis
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Anticonvulsants