Abstract
A case of human papillomavirus-associated condyloma acuminatum in the oral cavity, presumed to be fulminant cyclosporine-induced gingival hyperplasia, is reported in a 55-year-old cardiac transplant patient. Approximately 47 months following the transplant, the patient developed severe hyperplasia of the uvula and oral mucosa, resulting in difficulty swallowing. The histopathologic features of the lesion were typical of those of condyloma acuminatum. In situ hybridization of the paraffin-embedded material revealed infection with human papillomavirus types 6/11. This case lends further support to the putative role of long-term cellular immunosuppression in the development of human papillomavirus-associated squamous lesions. In addition, positive staining for p53 protein raises the possibility of concomitant p53 involvement in the pathogenesis of this oral lesion.
MeSH terms
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Condylomata Acuminata / diagnosis*
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Condylomata Acuminata / virology
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Cyclosporine / adverse effects
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Diagnosis, Differential
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Heart Transplantation / adverse effects
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Humans
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Immunocompromised Host*
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Immunosuppressive Agents / adverse effects
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In Situ Hybridization
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Male
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Middle Aged
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Mouth
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Mouth Diseases / diagnosis*
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Mouth Diseases / metabolism
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Mouth Diseases / virology
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Mouth Mucosa / metabolism
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Mouth Mucosa / pathology
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Mouth Mucosa / virology
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Papillomaviridae / genetics
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Papillomaviridae / isolation & purification*
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Papillomaviridae / pathogenicity
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Papillomavirus Infections / complications
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Papillomavirus Infections / diagnosis*
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Papillomavirus Infections / metabolism
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Postoperative Complications
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Tumor Suppressor Protein p53* / metabolism
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Uvula / metabolism
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Uvula / pathology
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Uvula / virology
Substances
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Immunosuppressive Agents
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Tumor Suppressor Protein p53
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Cyclosporine