Translocation (16;18)(p13;q21.3) in follicular lymphoma

Mandana Mahmoodi; Silvio S Tanev; Hope H Punnett; Pamela Crilley; J Steve Hou

doi:10.1016/j.cancergencyto.2004.02.008

Translocation (16;18)(p13;q21.3) in follicular lymphoma

Cancer Genet Cytogenet. 2004 Oct 15;154(2):160-2. doi: 10.1016/j.cancergencyto.2004.02.008.

Authors

Mandana Mahmoodi¹, Silvio S Tanev, Hope H Punnett, Pamela Crilley, J Steve Hou

Affiliation

¹ Department of Pathology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA.

PMID: 15474153
DOI: 10.1016/j.cancergencyto.2004.02.008

Abstract

We describe a novel t(16;18)(p13;q21.3) in a male patient with follicular lymphoma. This unique chromosomal rearrangement has never been described in patients with follicular lymphoma. The breakpoint of 16p13 has several hematopoietic neoplasm-related genes such as MHC2TA, a master regulatory gene for HLA-D, and BCMA, tumor necrosis factor receptor super-family. The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. The diagnostic and prognostic significance of this new translocation is yet to be determined.

Publication types

Case Reports

MeSH terms

Chromosomes, Human, Pair 16*
Chromosomes, Human, Pair 18*
Genes, bcl-2
Humans
Lymphoma, Follicular / genetics*
Male
Middle Aged
Translocation, Genetic*