Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics

S Anttila; A Illi; O Kampman; K M Mattila; T Lehtimäki; E Leinonen

doi:10.1007/s00702-004-0233-9

Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics

J Neural Transm (Vienna). 2005 Jul;112(7):885-90. doi: 10.1007/s00702-004-0233-9. Epub 2004 Nov 3.

Authors

S Anttila¹, A Illi, O Kampman, K M Mattila, T Lehtimäki, E Leinonen

Affiliation

¹ Department of Psychiatry, Tampere University Hospital, University of Tampere, Medical School, Tampere, Finland. samia@koti.soon.fi

PMID: 15526143
DOI: 10.1007/s00702-004-0233-9

Abstract

Several studies have connected brain-derived neurotrophic factor (BDNF) with treatment response to neuroleptics. In recent studies, the BDNF expression was reduced by typical neuroleptics. We conducted a retrospective study on 94 patients with schizophrenia and 98 controls. The BDNF G196A and C270T polymorphisms are not associated with treatment response to typical neuroleptics or with age at first hospitalization. Moreover, these polymorphisms of the BDNF gene are not associated with the risk of schizophrenia.

Publication types

Comparative Study

MeSH terms

Age of Onset
Antipsychotic Agents / therapeutic use*
Brain-Derived Neurotrophic Factor / genetics*
Drug Resistance
Gene Frequency
Genetic Predisposition to Disease
Haplotypes
Humans
Polymerase Chain Reaction
Polymorphism, Genetic*
Retrospective Studies
Schizophrenia / drug therapy*
Schizophrenia / genetics*

Substances

Antipsychotic Agents
Brain-Derived Neurotrophic Factor