The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis

Jonathan A Cohn; R Michael Mitchell; Paul S Jowell

doi:10.1016/j.gtc.2004.07.008

The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis

Gastroenterol Clin North Am. 2004 Dec;33(4):817-37, vii. doi: 10.1016/j.gtc.2004.07.008.

Authors

Jonathan A Cohn¹, R Michael Mitchell, Paul S Jowell

Affiliation

¹ Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA. cohn0001@mc.duke.edu

PMID: 15528020
DOI: 10.1016/j.gtc.2004.07.008

Abstract

This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Cholangitis, Sclerosing / genetics
Chronic Disease
Cystic Fibrosis / genetics
Cystic Fibrosis / physiopathology
Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
Genetic Predisposition to Disease*
Genetic Testing
Humans
Mutation*
Pancreatitis / genetics*
Pancreatitis / physiopathology
Trypsin Inhibitor, Kazal Pancreatic / genetics

Substances

CFTR protein, human
Cystic Fibrosis Transmembrane Conductance Regulator
Trypsin Inhibitor, Kazal Pancreatic