The CCR5Delta32 allele is associated with reduced liver inflammation in hepatitis C virus infection

Eur J Immunogenet. 2004 Dec;31(6):249-52. doi: 10.1111/j.1365-2370.2004.00482.x.

Abstract

CCR5Delta32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Delta32 allele. The CCR5Delta32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Hepacivirus / metabolism
  • Hepatitis C / metabolism*
  • Heterozygote
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Inflammation / virology
  • Liver / metabolism*
  • Liver / virology
  • Male
  • Middle Aged
  • Mutation*
  • Receptors, CCR5 / genetics*
  • Receptors, CCR5 / metabolism

Substances

  • Receptors, CCR5