The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki; Megumi Kurita; Kiyohisa Mizumoto; Masatsugu Moriyama; Sadakazu Aiso; Ikuo Nishimoto; Masaaki Matsuoka

doi:10.1016/j.bbrc.2004.11.016

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Biochem Biophys Res Commun. 2005 Jan 7;326(1):242-8. doi: 10.1016/j.bbrc.2004.11.016.

Authors

Hiroaki Suzuki¹, Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

Affiliation

¹ Department of Pharmacology, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan.

PMID: 15567177
DOI: 10.1016/j.bbrc.2004.11.016

Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Binding Sites
COS Cells
Cell Line
Chlorocebus aethiops
Cyclin-Dependent Kinase Inhibitor p16
DNA-Binding Proteins / metabolism*
Down-Regulation*
Humans
Mice
Osteosarcoma / metabolism*
Protein Binding
Protein Structure, Tertiary
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-bcl-6
Transcription Factors / metabolism*
Transcriptional Activation*
Tumor Suppressor Protein p14ARF / metabolism*
Tumor Suppressor Proteins / metabolism*

Substances

Cdkn2a protein, mouse
Cyclin-Dependent Kinase Inhibitor p16
DNA-Binding Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-6
Transcription Factors
Tumor Suppressor Protein p14ARF
Tumor Suppressor Proteins