Abstract
Introduction:
Nearly 50 % of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability.
Method:
We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent.
Result:
21 % of the alcoholics fulfilled DSM-IV-criteria of ADHD with ongoing symptoms in adulthood. There was no significant difference in 5-HTT- or 5-HT2c-allele distribution between alcoholics and matched controls or between alcoholics with or without ADHD.
Conclusion:
In our sample the functional relevant 5-HTT-promoter and the 5-HT2c-receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
MeSH terms
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Adolescent
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Adult
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Aged
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Alcoholism / epidemiology
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Alcoholism / genetics*
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Alcoholism / rehabilitation
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Alleles
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Attention Deficit Disorder with Hyperactivity / epidemiology
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Attention Deficit Disorder with Hyperactivity / genetics*
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Attention Deficit Disorder with Hyperactivity / rehabilitation
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Comorbidity
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Female
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Genetic Predisposition to Disease / genetics*
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Genotype
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Humans
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Male
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Membrane Glycoproteins / genetics
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Membrane Transport Proteins / genetics
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Middle Aged
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Nerve Tissue Proteins / genetics
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Patient Admission
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Phenotype
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Polymorphism, Genetic
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Promoter Regions, Genetic
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Receptor, Serotonin, 5-HT2C / genetics
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Serotonin Plasma Membrane Transport Proteins
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Statistics as Topic
Substances
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Receptor, Serotonin, 5-HT2C
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins