Is there a link between malignant hyperthermia and exertional heat illness?

Exerc Sport Sci Rev. 2004 Oct;32(4):174-9. doi: 10.1097/00003677-200410000-00009.

Abstract

Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions. It has been suggested that a subset of MH susceptible persons may be predisposed to EHI. We examine the current understanding of these disorders and explore evidence of a relationship. Screening for the muscle type I ryanodine receptor gene should help clarify the relationship between MH and EHI.

Publication types

  • Case Reports

MeSH terms

  • Acidosis / genetics
  • Acidosis / metabolism
  • Adolescent
  • Child
  • Dantrolene / therapeutic use
  • Fatal Outcome
  • Genetic Predisposition to Disease
  • Heat Exhaustion / drug therapy
  • Heat Exhaustion / genetics
  • Heat Exhaustion / physiopathology
  • Heat Stress Disorders / drug therapy
  • Heat Stress Disorders / genetics
  • Heat Stress Disorders / physiopathology*
  • Humans
  • Male
  • Malignant Hyperthermia / drug therapy
  • Malignant Hyperthermia / genetics
  • Malignant Hyperthermia / physiopathology*
  • Muscle Relaxants, Central / therapeutic use
  • Mutation
  • Physical Exertion*
  • Risk Factors
  • Ryanodine Receptor Calcium Release Channel / genetics
  • Ryanodine Receptor Calcium Release Channel / metabolism

Substances

  • Muscle Relaxants, Central
  • Ryanodine Receptor Calcium Release Channel
  • Dantrolene