Abstract
Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions. It has been suggested that a subset of MH susceptible persons may be predisposed to EHI. We examine the current understanding of these disorders and explore evidence of a relationship. Screening for the muscle type I ryanodine receptor gene should help clarify the relationship between MH and EHI.
MeSH terms
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Acidosis / genetics
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Acidosis / metabolism
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Adolescent
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Child
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Dantrolene / therapeutic use
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Fatal Outcome
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Genetic Predisposition to Disease
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Heat Exhaustion / drug therapy
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Heat Exhaustion / genetics
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Heat Exhaustion / physiopathology
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Heat Stress Disorders / drug therapy
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Heat Stress Disorders / genetics
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Heat Stress Disorders / physiopathology*
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Humans
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Male
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Malignant Hyperthermia / drug therapy
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Malignant Hyperthermia / genetics
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Malignant Hyperthermia / physiopathology*
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Muscle Relaxants, Central / therapeutic use
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Mutation
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Physical Exertion*
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Risk Factors
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Ryanodine Receptor Calcium Release Channel / genetics
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Ryanodine Receptor Calcium Release Channel / metabolism
Substances
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Muscle Relaxants, Central
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Ryanodine Receptor Calcium Release Channel
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Dantrolene