Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients

B Tarnowski; A Chudecka-Głaz; B Górski; I Rzepka-Górska

doi:10.1007/s10549-004-0779-0

Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients

Breast Cancer Res Treat. 2004 Dec;88(3):287-8. doi: 10.1007/s10549-004-0779-0.

Authors

B Tarnowski¹, A Chudecka-Głaz, B Górski, I Rzepka-Górska

Affiliation

¹ Department of Gynecological Surgery and Oncology of Adults and Adolescents, Hereditary Cancer Center, Szczecin, Poland.

PMID: 15609132
DOI: 10.1007/s10549-004-0779-0

Abstract

The aim of the study was to compare VEGF serum levels in breast cancer patients with and without BRCA1 gene mutation. We enrolled 80 patients, 22 premenopausal and 58 postmenopausal. We found statistically significant lower levels of VEGF in patients with BRCA1 gene mutation as compared with breast cancer patients without this mutation.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / blood
Breast Neoplasms / genetics*
Female
Genes, BRCA1 / physiology*
Humans
Menopause / genetics
Mutation
Ovarian Neoplasms / blood
Ovarian Neoplasms / genetics
Vascular Endothelial Growth Factor A / blood*

Substances

Vascular Endothelial Growth Factor A