A major genotype in UDP-glucuronosyltransferase 2B15

Kenji Toide; Shin-Ichiro Umeda; Hiroshi Yamazaki; Yoshiki Takahashi; Yoshiaki Terauchi; Toshihiko Fujii; Tetsuya Kamataki

doi:10.2133/dmpk.17.164

A major genotype in UDP-glucuronosyltransferase 2B15

Drug Metab Pharmacokinet. 2002;17(2):164-6. doi: 10.2133/dmpk.17.164.

Authors

Kenji Toide¹, Shin-Ichiro Umeda, Hiroshi Yamazaki, Yoshiki Takahashi, Yoshiaki Terauchi, Toshihiko Fujii, Tetsuya Kamataki

Affiliation

¹ Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

PMID: 15618667
DOI: 10.2133/dmpk.17.164

Abstract

A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'. This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.