Abstract
Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Cohort Studies
-
Drug Hypersensitivity / genetics*
-
Drug Hypersensitivity / immunology
-
Female
-
Genetic Predisposition to Disease / genetics*
-
HLA Antigens / genetics
-
HLA Antigens / immunology
-
HLA-A Antigens / genetics*
-
HLA-A Antigens / immunology
-
HLA-DRB1 Chains
-
Humans
-
Immunity, Cellular / genetics
-
Immunity, Cellular / immunology
-
Male
-
Nevirapine / adverse effects*
-
Reverse Transcriptase Inhibitors / adverse effects*
Substances
-
HLA Antigens
-
HLA-A Antigens
-
HLA-DRB1 Chains
-
HLA-DRB1*01:01 antigen
-
Reverse Transcriptase Inhibitors
-
Nevirapine