Myocarditis and sacroiliitis: 2 previously unrecognized manifestations of tumor necrosis factor receptor associated periodic syndrome

Stephanie Trost; Carlos D Rosé

Myocarditis and sacroiliitis: 2 previously unrecognized manifestations of tumor necrosis factor receptor associated periodic syndrome

J Rheumatol. 2005 Jan;32(1):175-7.

Authors

Stephanie Trost¹, Carlos D Rosé

Affiliation

¹ Department of Rheumatology, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.

PMID: 15630744

Abstract

Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is an autosomic-dominant periodic syndrome associated with mutations in the extracellular domain of the 55 kDa TNF receptor. Clinically, episodes of severe myalgia, arthralgia/arthritis, sterile peritonitis, scrotal inflammation, serositis, migratory rash, conjunctivitis, and recurrent fever are characteristic. We describe a 9-year-old African American boy with the P46L mutation of the TNF receptor who presented with 2 previously unrecognized manifestations: sacroiliitis and myocardiopathy, both showing a reversible course.

Publication types

Case Reports

MeSH terms

Arthritis / diagnosis*
Arthritis / drug therapy
Arthritis / genetics
Child
Familial Mediterranean Fever / diagnosis*
Familial Mediterranean Fever / drug therapy
Familial Mediterranean Fever / genetics
Glucocorticoids / therapeutic use
Heterozygote
Humans
Indomethacin / therapeutic use
Male
Methylprednisolone / therapeutic use
Mutation / genetics
Myocarditis / diagnosis*
Myocarditis / drug therapy
Myocarditis / genetics
Radionuclide Imaging
Receptors, Tumor Necrosis Factor, Type I / genetics*
Recovery of Function
Sacroiliac Joint / diagnostic imaging
Sacroiliac Joint / pathology*
Tomography, X-Ray Computed
Treatment Outcome

Substances

Glucocorticoids
Receptors, Tumor Necrosis Factor, Type I
Methylprednisolone
Indomethacin