Abstract
Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Cycle
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Cerebellar Neoplasms / embryology
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Cerebellar Neoplasms / metabolism*
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Cerebellum / embryology
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Cerebellum / growth & development
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Cerebellum / metabolism*
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Hedgehog Proteins
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism
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Medulloblastoma / embryology
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Medulloblastoma / metabolism*
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Mice
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Mice, Mutant Strains
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Mice, Transgenic
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Polycomb Repressive Complex 1
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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Receptors, Notch
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Signal Transduction
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Wnt Proteins
Substances
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BMI1 protein, human
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Bmi1 protein, mouse
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Hedgehog Proteins
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Intercellular Signaling Peptides and Proteins
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Membrane Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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Receptors, Notch
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Repressor Proteins
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SHH protein, human
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Trans-Activators
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Wnt Proteins
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Polycomb Repressive Complex 1