Abstract
Recent studies have indicated that proteins in the transforming growth factor-beta superfamily alter damage induced by various neuronal injuries. Of these proteins, glial cell line-derived neurotrophic factor (GDNF) and bone morphogenetic protein-7 (BMP-7) have unique protective and regenerative effects in stroke animals. Delivery of GDNF or BMP-7 to brain tissue reduced cerebral infarction and improved motor functions in stroke animals. Pretreatment with these factors reduced caspase-3 activity and DNA fragmentation in the ischemic brain region, suggesting that antiapoptotic effects are involved. Beside the protective effects, BMP-7 given after stroke improves locomotor function. These regenerative effects of BMP-7 may involve the enhancement of dendritic growth and remodeling. In this review, we illustrate the neuroprotective and neuroregenerative properties of GDNF and BMP-7 and emphasize their therapeutic potential for stroke.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Bone Morphogenetic Protein 7
-
Bone Morphogenetic Proteins / genetics
-
Bone Morphogenetic Proteins / physiology*
-
Bone Morphogenetic Proteins / therapeutic use
-
Brain Ischemia / physiopathology
-
Brain Ischemia / prevention & control
-
Cell Transplantation
-
Clinical Trials as Topic
-
Genetic Therapy
-
Glial Cell Line-Derived Neurotrophic Factor
-
Humans
-
Nerve Growth Factors / genetics
-
Nerve Growth Factors / physiology*
-
Nerve Growth Factors / therapeutic use
-
Neuroprotective Agents / therapeutic use
-
Parkinson Disease / drug therapy
-
Stroke / metabolism*
-
Stroke / therapy
-
Transforming Growth Factor beta / genetics
-
Transforming Growth Factor beta / physiology*
-
Transforming Growth Factor beta / therapeutic use
Substances
-
BMP7 protein, human
-
Bone Morphogenetic Protein 7
-
Bone Morphogenetic Proteins
-
GDNF protein, human
-
Glial Cell Line-Derived Neurotrophic Factor
-
Nerve Growth Factors
-
Neuroprotective Agents
-
Transforming Growth Factor beta