Sexual dysfunction associated with neuroleptic-induced hyperprolactinemia improves with reduction in prolactin levels

Ann N Y Acad Sci. 2004 Dec:1032:289-90. doi: 10.1196/annals.1314.041.

Abstract

We attempt to demonstrate the association between neuroleptic-induced hyperprolactinemia and sexual dysfunction in schizophrenic patients treated with prolactin-elevating antipsychotics. Our findings indicate that sexual function improved with euprolactinemia in patients switched from treatment with prolactin-elevating antipsychotics to olanzapine.

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Benzodiazepines / adverse effects
  • Benzodiazepines / therapeutic use
  • Ejaculation / drug effects
  • Female
  • Humans
  • Hyperprolactinemia / blood*
  • Hyperprolactinemia / chemically induced*
  • Male
  • Olanzapine
  • Prolactin / blood*
  • Psychotic Disorders / complications
  • Psychotic Disorders / drug therapy
  • Risperidone / adverse effects
  • Risperidone / therapeutic use
  • Sex Characteristics
  • Sexual Dysfunction, Physiological / blood*
  • Sexual Dysfunction, Physiological / chemically induced*
  • Sexual Dysfunctions, Psychological / chemically induced
  • Sexual Dysfunctions, Psychological / psychology

Substances

  • Antipsychotic Agents
  • Benzodiazepines
  • Prolactin
  • Risperidone
  • Olanzapine