Chronic Burkholderia multivorans bronchial infection in a non-cystic fibrosis individual with mannose binding lectin deficiency

J L Whitehouse; A R Exley; J Foweraker; D Bilton

doi:10.1136/thx.2003.016493

Chronic Burkholderia multivorans bronchial infection in a non-cystic fibrosis individual with mannose binding lectin deficiency

Thorax. 2005 Feb;60(2):168-70. doi: 10.1136/thx.2003.016493.

Authors

J L Whitehouse¹, A R Exley, J Foweraker, D Bilton

Affiliation

¹ Lung Defence Clinic, Papworth Hospital, Papworth St Everard, Cambridgeshire CB3 8RE, UK. jo_wh@excite.com

Abstract

The case history is presented of a woman with multiple respiratory infections and mannose binding lectin (MBL) deficiency but no evidence of bronchiectasis who developed a chronic Burkholderia multivorans infection. Careful microbiological assessment is needed in patients with recurrent respiratory infection and the presence of B multivorans should trigger further immunological investigation including assessment of MBL status.

Publication types

Case Reports

MeSH terms

Adult
Burkholderia Infections / drug therapy*
Burkholderia Infections / genetics
Burkholderia cepacia / genetics*
Chronic Disease
Female
Genotype
Heterozygote
Humans
Mannose-Binding Lectin / analogs & derivatives*
Mannose-Binding Lectin / deficiency*
Mannose-Binding Lectin / genetics
Polymorphism, Genetic
Recurrence
Respiratory Tract Infections / drug therapy*
Respiratory Tract Infections / microbiology

Substances

MBL2 protein, human
Mannose-Binding Lectin