Abstract
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Aged
-
Aged, 80 and over
-
Alzheimer Disease / genetics
-
Alzheimer Disease / metabolism*
-
Alzheimer Disease / physiopathology
-
Analysis of Variance
-
Animals
-
Anxiety / etiology
-
Anxiety / metabolism*
-
Apolipoproteins E / deficiency*
-
Apolipoproteins E / genetics
-
Apolipoproteins E / metabolism
-
Behavior, Animal
-
Female
-
Glucocorticoids / cerebrospinal fluid
-
Humans
-
Hydrocortisone / cerebrospinal fluid
-
Immunohistochemistry / methods
-
Male
-
Maze Learning / physiology
-
Mice
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Middle Aged
-
Protein Isoforms / metabolism*
-
Reflex, Acoustic / genetics
-
Sex Factors
-
Sleep Apnea, Central / complications
Substances
-
Apolipoproteins E
-
Glucocorticoids
-
Protein Isoforms
-
Hydrocortisone