Abstract
Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL). Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model. IL-15, but not IL-2, was preferentially elevated in patients' serum. AKT and IL-15 may be important in ENTL tumor survival.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Survival
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Humans
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Immunohistochemistry
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Immunophenotyping
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Interleukin-15 / blood
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Interleukin-15 / metabolism
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Interleukin-2 / metabolism
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Killer Cells, Natural / cytology*
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Lymphoma / pathology
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Lymphoma, T-Cell / enzymology
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Lymphoma, T-Cell / immunology*
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Nose Neoplasms / enzymology
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Nose Neoplasms / immunology*
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Phosphorylation
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Proto-Oncogene Proteins c-akt / metabolism
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Proto-Oncogene Proteins c-akt / physiology*
Substances
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Interleukin-15
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Interleukin-2
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Proto-Oncogene Proteins c-akt