Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript

Histopathology. 2005 Mar;46(3):334-41. doi: 10.1111/j.1365-2559.2005.02064.x.

Abstract

Aims: To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confused with primary or metastatic carcinoma.

Methods and results: Molecular analysis demonstrated for the first time the presence of FUS-CHOP transcript in this liposarcoma variant. Microarray analysis revealed a gene expression profile related to a more aggressive tumour type when compared with other myxoid/round cell liposarcomas.

Conclusions: The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD34 / analysis
  • Biomarkers
  • CCAAT-Enhancer-Binding Proteins / genetics*
  • Cluster Analysis
  • Diagnosis, Differential
  • Female
  • Fibronectins / analysis
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Keratins / analysis
  • Liposarcoma / genetics
  • Liposarcoma / metabolism
  • Liposarcoma / pathology*
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Oncogene Proteins, Fusion / genetics*
  • RNA, Neoplasm / genetics
  • RNA, Neoplasm / metabolism
  • RNA-Binding Protein FUS / genetics*
  • Receptor, Fibroblast Growth Factor, Type 4
  • Receptors, Fibroblast Growth Factor / analysis
  • Transcription Factor CHOP
  • Transcription, Genetic / genetics
  • Vimentin / analysis

Substances

  • Antigens, CD34
  • Biomarkers
  • CAM 5.2 antigen
  • CCAAT-Enhancer-Binding Proteins
  • Fibronectins
  • Oncogene Proteins, Fusion
  • RNA, Neoplasm
  • RNA-Binding Protein FUS
  • Receptors, Fibroblast Growth Factor
  • TLS-CHOP fusion protein, human
  • Vimentin
  • Transcription Factor CHOP
  • Keratins
  • FGFR4 protein, human
  • Receptor, Fibroblast Growth Factor, Type 4