Atopy parameters in asthmatic children increase with accumulation of null-alleles of glutathione-S-transferase M1

S I Makarova; O G Safronova; V A Vavilin; O A Batychko; S M Gavalov; V V Lyakhovich

doi:10.1007/s10517-005-0070-3

Atopy parameters in asthmatic children increase with accumulation of null-alleles of glutathione-S-transferase M1

Bull Exp Biol Med. 2004 Nov;138(5):460-2. doi: 10.1007/s10517-005-0070-3.

Authors

S I Makarova¹, O G Safronova, V A Vavilin, O A Batychko, S M Gavalov, V V Lyakhovich

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. makar@soramn.ru

PMID: 15723126
DOI: 10.1007/s10517-005-0070-3

Abstract

Atopy parameters (total IgE, skin prick test, and peripheral blood eosinophil count) in children with atopic bronchial asthma depend on the number of glutathione-S-transferase M1 mutant alleles in the genotype and on family history of asthma.

MeSH terms

Alleles
Asthma / blood
Asthma / enzymology
Asthma / genetics*
Child
Eosinophils
Genotype
Glutathione Transferase / genetics*
Humans
Hypersensitivity, Immediate / blood
Hypersensitivity, Immediate / enzymology
Hypersensitivity, Immediate / genetics*
Immunoglobulin E / blood
Leukocyte Count
Skin Tests

Substances

Immunoglobulin E
Glutathione Transferase
glutathione S-transferase M1