Abstract
Background:
The imprinted genes insulin-like growth factor 2 (IGF2) and H19 play important roles in various malignancies including hepatocellular carcinoma (HCC).
Materials and methods:
We used DNA microarray and patient follow-up data to examine the relationship between expression of IGF2 and H19 and HCC.
Results:
We found that imbalances in levels of IGF2 and H19 transcripts were correlated with advanced tumor stage and poor outcome in HCC patients.
Conclusion:
In addition to their known epigenetic or genetic abnormality in malignancies, these findings suggest that altered transcription of these two imprinted genes contributes to progression of HCC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Carcinoma, Hepatocellular / genetics
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Carcinoma, Hepatocellular / metabolism*
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Carcinoma, Hepatocellular / pathology
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Cohort Studies
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Disease Progression
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Female
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Gene Expression
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Humans
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Insulin-Like Growth Factor II / biosynthesis*
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Insulin-Like Growth Factor II / genetics
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Liver Neoplasms / genetics
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Liver Neoplasms / metabolism*
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Liver Neoplasms / pathology
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Male
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Middle Aged
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Neoplasm Staging
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Oligonucleotide Array Sequence Analysis
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RNA, Long Noncoding
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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RNA, Untranslated / biosynthesis*
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RNA, Untranslated / genetics
Substances
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H19 long non-coding RNA
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RNA, Long Noncoding
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RNA, Messenger
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RNA, Untranslated
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Insulin-Like Growth Factor II