Imbalance in expression levels of insulin-like growth factor 2 and H19 transcripts linked to progression of hepatocellular carcinoma

Anticancer Res. 2004 Nov-Dec;24(6):4085-9.

Abstract

Background: The imprinted genes insulin-like growth factor 2 (IGF2) and H19 play important roles in various malignancies including hepatocellular carcinoma (HCC).

Materials and methods: We used DNA microarray and patient follow-up data to examine the relationship between expression of IGF2 and H19 and HCC.

Results: We found that imbalances in levels of IGF2 and H19 transcripts were correlated with advanced tumor stage and poor outcome in HCC patients.

Conclusion: In addition to their known epigenetic or genetic abnormality in malignancies, these findings suggest that altered transcription of these two imprinted genes contributes to progression of HCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / pathology
  • Cohort Studies
  • Disease Progression
  • Female
  • Gene Expression
  • Humans
  • Insulin-Like Growth Factor II / biosynthesis*
  • Insulin-Like Growth Factor II / genetics
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oligonucleotide Array Sequence Analysis
  • RNA, Long Noncoding
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • RNA, Untranslated / biosynthesis*
  • RNA, Untranslated / genetics

Substances

  • H19 long non-coding RNA
  • RNA, Long Noncoding
  • RNA, Messenger
  • RNA, Untranslated
  • Insulin-Like Growth Factor II