T homozygote and allele of epidermal growth factor receptor 2073 gene polymorphism are associated with higher susceptibility to endometriosis and leiomyomas

Yao-Yuan Hsieh; Chi-Chen Chang; Fuu-Jen Tsai; Cheng-Chieh Lin; Chang-Hai Tsai

doi:10.1016/j.fertnstert.2004.08.032

T homozygote and allele of epidermal growth factor receptor 2073 gene polymorphism are associated with higher susceptibility to endometriosis and leiomyomas

Fertil Steril. 2005 Mar;83(3):796-9. doi: 10.1016/j.fertnstert.2004.08.032.

Authors

Yao-Yuan Hsieh¹, Chi-Chen Chang, Fuu-Jen Tsai, Cheng-Chieh Lin, Chang-Hai Tsai

Affiliation

¹ Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.

PMID: 15749523
DOI: 10.1016/j.fertnstert.2004.08.032

Abstract

Epidermal growth factor receptor (EGFR) is a regulator of angiogenesis and mediator of sex steroid-induced cell growth and differentiation. We observed that EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma.

MeSH terms

Endometriosis / genetics*
ErbB Receptors / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Heterozygote
Homozygote
Humans
Leiomyoma / genetics*
Polymorphism, Genetic*
Uterine Neoplasms / genetics*

Substances

ErbB Receptors