Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

P Alhopuro; P Katajisto; R Lehtonen; S K Ylisaukko-Oja; L Näätsaari; A Karhu; A M Westerman; J H P Wilson; F W M de Rooij; T Vogel; G Moeslein; I P Tomlinson; L A Aaltonen; T P Mäkelä; V Launonen

doi:10.1038/sj.bjc.6602454

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

Br J Cancer. 2005 Mar 28;92(6):1126-9. doi: 10.1038/sj.bjc.6602454.

Authors

P Alhopuro¹, P Katajisto, R Lehtonen, S K Ylisaukko-Oja, L Näätsaari, A Karhu, A M Westerman, J H P Wilson, F W M de Rooij, T Vogel, G Moeslein, I P Tomlinson, L A Aaltonen, T P Mäkelä, V Launonen

Affiliation

¹ Department of Medical Genetics, Biomedicum Helsinki (Haartmaninkatu 8), University of Helsinki, Helsinki FIN-00014, Finland.

Abstract

Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adaptor Proteins, Vesicular Transport / genetics*
DNA Helicases
Humans
Introns
Mutation*
Nuclear Proteins / genetics*
Peutz-Jeghers Syndrome / genetics*
Polymorphism, Genetic
Transcription Factors / genetics*

Substances

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Nuclear Proteins
STRADA protein, human
Transcription Factors
SMARCA4 protein, human
DNA Helicases