Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization

Yoshifumi Makimoto; Kazuki Nabeshima; Hiroshi Iwasaki; Akiko Ishiguro; Tatsu Miyoshi; Takeshi Shiraishi; Akinori Iwasaki; Takayuki Shirakusa

doi:10.1007/s00428-004-1170-6

Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization

Virchows Arch. 2005 Apr;446(4):451-5. doi: 10.1007/s00428-004-1170-6. Epub 2005 Mar 19.

Authors

Yoshifumi Makimoto¹, Kazuki Nabeshima, Hiroshi Iwasaki, Akiko Ishiguro, Tatsu Miyoshi, Takeshi Shiraishi, Akinori Iwasaki, Takayuki Shirakusa

Affiliation

¹ Department of Pathology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka , Japan.

PMID: 15778844
DOI: 10.1007/s00428-004-1170-6

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that usually occurs in children and young adults. Anaplastic lymphoma kinase (ALK) abnormalities in IMT, determined using immunohistochemistry and/or molecular genetic studies, including fluorescence in situ hybridization (FISH), have almost been limited to children and young adults. In elderly cases of IMT, these ALK abnormalities are very rare. We report on a case of IMT arising in the posterior mediastinum of a 59-year-old Japanese man that showed ALK abnormalities determined using immunohistochemistry and FISH, suggesting the neoplastic nature of a subset of IMTs in older patients similar to those in younger ones and the presence of an additional mechanism(s) that allows them to start to grow late.

Publication types

Case Reports

MeSH terms

Anaplastic Lymphoma Kinase
Biomarkers, Tumor / metabolism
Diagnosis, Differential
Fibroblasts / enzymology
Fibroblasts / pathology
Fibroma / diagnosis
Gene Rearrangement
Humans
Immunoenzyme Techniques
In Situ Hybridization, Fluorescence
Male
Mediastinal Neoplasms / enzymology
Mediastinal Neoplasms / genetics
Mediastinal Neoplasms / pathology*
Mediastinal Neoplasms / surgery
Middle Aged
Neoplasms, Muscle Tissue / enzymology
Neoplasms, Muscle Tissue / genetics
Neoplasms, Muscle Tissue / pathology*
Neoplasms, Muscle Tissue / surgery
Neurofibrosarcoma / diagnosis
Protein-Tyrosine Kinases / metabolism*
Radiography, Thoracic
Receptor Protein-Tyrosine Kinases
Treatment Outcome

Substances

Biomarkers, Tumor
ALK protein, human
Anaplastic Lymphoma Kinase
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases