Abstract
Purpose and methods:
In this study, we examined the combined methylation status of HLTF, SOCS-1, and CDH13 in 61 resected primary colorectal cancers using methylation-specific polymerase chain reaction and correlated the number of methylated genes with the clinicopathologic features of affected patients.
Results:
We found a significant difference in lymph node metastasis (P = 0.020) when we compared the number of methylated genes in colorectal cancers with lymph node metastasis to those without it.
Conclusions:
Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF , SOCS-1 , and CDH13 genes.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Cadherins / genetics*
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / pathology*
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DNA Methylation*
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DNA-Binding Proteins / genetics*
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Female
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Humans
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Intracellular Signaling Peptides and Proteins / genetics*
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Lymphatic Metastasis
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Male
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Middle Aged
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Polymerase Chain Reaction
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Repressor Proteins / genetics*
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Transcription Factors / genetics*
Substances
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Cadherins
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DNA-Binding Proteins
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H-cadherin
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HLTF protein, human
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Intracellular Signaling Peptides and Proteins
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Repressor Proteins
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SOCS1 protein, human
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Transcription Factors