Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation

J Heart Lung Transplant. 2005 Apr;24(4):493-7. doi: 10.1016/j.healun.2004.02.010.

Abstract

We investigated the functional promoter repeat polymorphism (GT)(n) in the oxidative stress-induced enzyme heme oxygenase-1 in relation to heart failure and complications after transplantation. No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biopsy
  • Coronary Angiography
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / genetics
  • Coronary Vessels / pathology
  • DNA / genetics
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Graft Rejection / genetics
  • Graft Survival / genetics
  • Heart Failure / blood*
  • Heart Failure / surgery
  • Heart Transplantation* / adverse effects
  • Heme Oxygenase (Decyclizing) / genetics*
  • Heme Oxygenase (Decyclizing) / metabolism
  • Humans
  • Male
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Myocardium / pathology
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic / genetics*
  • Retrospective Studies
  • Risk Factors
  • Tissue Donors

Substances

  • DNA
  • Heme Oxygenase (Decyclizing)