Conclusion: Patients who carry the T/T homozygote of CYP17 C/T gene polymorphism may have a higher risk of developing oral cancer.
Objective: Cancer of the oral cavity is the most commonly seen malignancy in Taiwan, and its rising incidence poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Tumor necrosis factor-alpha (TNF-alpha) is one of the cytokines produced by macrophages, and its function has been postulated to play a role in cancer formation. We investigated whether polymorphisms of CYP17 and TNF-alpha genes are associated with oral cancer.
Material and methods: Polymorphisms of CYP17 and TNF-alpha genes were detected by polymerase chain reaction-based restriction analysis in 137 patients with oral cancer and 102 normal controls.
Results: The results for the CYP17 gene revealed a significant difference between oral cancer patients and normal controls (p =0.0063), but there was no significant difference for the TNF-alpha gene (p =0.4753).