Simultaneous onset of pemphigus vulgaris in two Turkish siblings

J Dermatol. 2005 Mar;32(3):186-8. doi: 10.1111/j.1346-8138.2005.tb00742.x.

Abstract

The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease*
  • HLA-DQ Antigens / genetics*
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Mouth Mucosa / pathology
  • Pemphigus / diagnosis*
  • Pemphigus / genetics*
  • Polymorphism, Genetic*
  • Risk Assessment
  • Severity of Illness Index
  • Siblings
  • Turkey

Substances

  • HLA-DQ Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains