A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

Katharina Walch; Friedrich Nagele; Robert Zeillinger; Elisabeth Vytiska-Binstorfer; Johannes C Huber; Lukas A Hefler

doi:10.1016/j.fertnstert.2004.11.043

A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

Fertil Steril. 2005 May;83(5):1565-7. doi: 10.1016/j.fertnstert.2004.11.043.

Authors

Katharina Walch¹, Friedrich Nagele, Robert Zeillinger, Elisabeth Vytiska-Binstorfer, Johannes C Huber, Lukas A Hefler

Affiliation

¹ Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria. katharina.walch@meduniwien.ac.at

PMID: 15866608
DOI: 10.1016/j.fertnstert.2004.11.043

Abstract

A common -1607 GG/G polymorphism of the matrix metalloproteinase-1 (MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case-control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles*
Case-Control Studies
Confidence Intervals
Female
Humans
Matrix Metalloproteinase 1 / genetics*
Odds Ratio
Polycystic Ovary Syndrome / genetics*
Polymorphism, Genetic / genetics*
Prospective Studies
White People / genetics*

Substances

Matrix Metalloproteinase 1