GSTT1 and GSTM1 polymorphisms are associated with improvement in seminal findings after varicocelectomy

Kazutoshi Okubo; Kanji Nagahama; Toshiyuki Kamoto; Hiroshi Okuno; Osamu Ogawa; Hiroyuki Nishiyama

doi:10.1016/j.fertnstert.2004.11.057

GSTT1 and GSTM1 polymorphisms are associated with improvement in seminal findings after varicocelectomy

Fertil Steril. 2005 May;83(5):1579-80. doi: 10.1016/j.fertnstert.2004.11.057.

Authors

Kazutoshi Okubo¹, Kanji Nagahama, Toshiyuki Kamoto, Hiroshi Okuno, Osamu Ogawa, Hiroyuki Nishiyama

Affiliation

¹ Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

PMID: 15866612
DOI: 10.1016/j.fertnstert.2004.11.057

Abstract

To identify the best candidates for varicocelectomy, we evaluated the genetic polymorphism in glutathione S-transferase (GST) T1 and M1 in 38 infertile men with high-grade varicocele testis who underwent varicocelectomy. The response rate to varicocelectomy is significantly higher in patients with the GSTT1-wt genotype than the GSTT1-null genotype, and the response rate became higher in combination with the GSTM1 genotype.

Publication types

Comparative Study
Congress
Research Support, Non-U.S. Gov't

MeSH terms

Chi-Square Distribution
Confidence Intervals
Glutathione Transferase / genetics*
Humans
Male
Odds Ratio
Polymorphism, Genetic / genetics*
Semen / cytology*
Semen / physiology
Sperm Count / statistics & numerical data
Statistics, Nonparametric
Varicocele / genetics*
Varicocele / surgery*

Substances

glutathione S-transferase T1
Glutathione Transferase
glutathione S-transferase M1