Chronic pancreatitis with pancreaticolithiasis and pseudocyst in a 5-year-old boy with homozygous SPINK1 mutation

Axel C Kühn; Niels Teich; Karel Caca; Anne Limbach; Wolfgang Hirsch

doi:10.1007/s00247-005-1477-8

Chronic pancreatitis with pancreaticolithiasis and pseudocyst in a 5-year-old boy with homozygous SPINK1 mutation

Pediatr Radiol. 2005 Sep;35(9):902-5. doi: 10.1007/s00247-005-1477-8. Epub 2005 May 5.

Authors

Axel C Kühn¹, Niels Teich, Karel Caca, Anne Limbach, Wolfgang Hirsch

Affiliation

¹ Department of Diagnostic Radiology -- Pediatric Radiology, Faculty of Medicine, University of Leipzig, Oststr. 21-25, 04317 Leipzig, Germany.

PMID: 15875176
DOI: 10.1007/s00247-005-1477-8

Abstract

We report a 5-year-old boy with a 5-month history of symptoms owing to chronic pancreatitis. Abdominal imaging revealed a large pseudocyst in the pancreatic tail and concretions in the main pancreatic duct. Successful endoscopic papillotomy and stent implantation were performed. Genetic testing showed homozygous SPINK1-N34S mutation, which is an established risk factor for chronic pancreatitis.

Publication types

Case Reports

MeSH terms

Child, Preschool
Cholangiopancreatography, Endoscopic Retrograde
Chronic Disease
Diagnosis, Differential
Diagnostic Imaging
Humans
Lithiasis / diagnosis*
Lithiasis / genetics*
Lithiasis / therapy
Male
Mutation
Pancreatic Diseases / diagnosis*
Pancreatic Diseases / genetics*
Pancreatic Diseases / therapy
Pancreatic Pseudocyst / diagnosis*
Pancreatic Pseudocyst / genetics*
Pancreatic Pseudocyst / therapy
Pancreatitis / diagnosis*
Pancreatitis / genetics*
Pancreatitis / therapy
Stents
Trypsin Inhibitor, Kazal Pancreatic / genetics*

Substances

Trypsin Inhibitor, Kazal Pancreatic