FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock

Clin Infect Dis. 2005 Jun 1;40(11):1679-83. doi: 10.1086/430065. Epub 2005 Apr 27.

Abstract

Individuals with deficiencies of the late components of complement exhibit a susceptibility to the recurrence of meningococcal disease with a usually mild clinical presentation. We report the recurrence of fulminant meningococcal disease in a complement component C7-deficient patient. We found a total deficiency of FcgammaRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antigens, CD / metabolism
  • Bacteremia
  • Complement C7 / deficiency*
  • Complement C7 / genetics
  • Female
  • GPI-Linked Proteins
  • Gene Expression
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Meningococcal Infections / genetics
  • Meningococcal Infections / metabolism*
  • Neutrophils / metabolism
  • Receptors, IgG / deficiency*
  • Receptors, IgG / metabolism
  • Recurrence
  • Shock, Septic / genetics
  • Shock, Septic / metabolism*

Substances

  • Antigens, CD
  • Complement C7
  • FCGR3B protein, human
  • GPI-Linked Proteins
  • Receptors, IgG