PTEN and Egr-1 expression in thyroid proliferative lesions

Carla Di Loreto; Gianluca Tell; Marta Pestrin; Maura Pandolfi; Giuseppe Damante; Fabio Puglisi

doi:10.1016/j.canlet.2004.10.014

PTEN and Egr-1 expression in thyroid proliferative lesions

Cancer Lett. 2005 Jun 16;224(1):105-9. doi: 10.1016/j.canlet.2004.10.014. Epub 2004 Nov 23.

Authors

Carla Di Loreto¹, Gianluca Tell, Marta Pestrin, Maura Pandolfi, Giuseppe Damante, Fabio Puglisi

Affiliation

¹ Anatomic Pathology, University of Udine, Udine, Italy.

PMID: 15911105
DOI: 10.1016/j.canlet.2004.10.014

Abstract

PTEN is a tumor suppressor gene that inhibits cell cycle progression. Recent data support that PTEN transcription is upregulated by Egr-1. The present study evaluated the immunohistochemical expression of PTEN and Egr-1 in normal thyroid and in its benign and malignant proliferative lesions. PTEN expression was cytoplasmic. The median percentage of normal cells with positive staining was 97.5%. It was similar in nodular hyperplasia, adenoma and papillary carcinoma. Follicular and undifferentiated carcinoma presented a significant decrease in the percentage of positive cells (P=0.027 and P=0.004). Egr-1 expression was nuclear. The median percentage of positivity was similar in normal tissue (29.75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively).

Publication types

Comparative Study

MeSH terms

Adenoma / genetics*
Adenoma / physiopathology*
Carcinoma, Papillary / genetics*
Carcinoma, Papillary / physiopathology*
Case-Control Studies
Cell Cycle
DNA-Binding Proteins / biosynthesis*
DNA-Binding Proteins / genetics*
Early Growth Response Protein 1
Gene Expression Profiling
Humans
Immediate-Early Proteins / biosynthesis*
Immediate-Early Proteins / genetics*
Immunohistochemistry
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases / biosynthesis*
Phosphoric Monoester Hydrolases / genetics*
Thyroid Diseases / genetics*
Thyroid Diseases / physiopathology*
Thyroid Neoplasms / genetics*
Thyroid Neoplasms / physiopathology*
Transcription Factors / biosynthesis*
Transcription Factors / genetics*
Tumor Suppressor Proteins / biosynthesis*
Tumor Suppressor Proteins / genetics*
Zinc Fingers

Substances

DNA-Binding Proteins
EGR1 protein, human
Early Growth Response Protein 1
Immediate-Early Proteins
Transcription Factors
Tumor Suppressor Proteins
Phosphoric Monoester Hydrolases
PTEN Phosphohydrolase
PTEN protein, human