Objective: To investigate the relationship of p53 protein expression and primary tumour volume in patients with nasopharyngeal carcinoma.
Design: Retrospective study.
Setting: Tertiary care centre.
Method: Forty-two newly diagnosed patients participated in the study.
Main outcome measures: The relationship between p53 status, TNM stage, and computed tomography-derived primary tumour volume.
Results: In patients with high p53 stains, the tumour volume was larger (p = .03). p53 was found to be independent of clinical stage (p = .84).
Conclusion: There is a positive correlation between primary tumour volume and p53 status.