Abstract
In multiple sclerosis patients, infection is often associated with disease deterioration. Lipopolysaccharide (LPS) from gram-negative bacteria signals via the toll-like receptor 4 (TLR-4) pathway. Therefore, we investigated the role of an Asp299Gly mutation in the TLR-4 receptor in 890 MS patients with multiple sclerosis and 350 healthy controls. No association of different genotypes with MS susceptibility, MS subtypes, or disease severity was found. In vitro LPS stimulation studies showed a significantly lower proliferation of PBMCs from donors heterozygous for the Asp299Gly mutation in comparison to PBMCs from individuals with the wild-type genotype (p=0.01). However, these functional changes seem not to have any impact on the clinical presentation of MS patients with different TLR-4 genotypes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Aspartic Acid / genetics*
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Cells, Cultured
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Cytokines / biosynthesis
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Disease Progression
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Germany
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Glycine / genetics*
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Humans
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Isoleucine / genetics
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Membrane Glycoproteins / biosynthesis
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Membrane Glycoproteins / genetics*
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Middle Aged
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Multiple Sclerosis / epidemiology
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / immunology*
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Polymorphism, Genetic*
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Receptors, Cell Surface / biosynthesis
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Receptors, Cell Surface / genetics*
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / metabolism
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Threonine / genetics
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Toll-Like Receptor 4
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Toll-Like Receptors
Substances
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Cytokines
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Membrane Glycoproteins
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Receptors, Cell Surface
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TLR4 protein, human
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Toll-Like Receptor 4
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Toll-Like Receptors
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Isoleucine
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Threonine
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Aspartic Acid
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Glycine