Periodic fever in children with hyperimmunoglobulinemia D and mevalonate kinase mutations

Pediatr Infect Dis J. 2005 Jun;24(6):573-4. doi: 10.1097/01.inf.0000164797.87474.b5.

Abstract

Hyperimmunoglobulinemia D syndrome (HIDS) is one cause of periodic fevers in children. HIDS is associated with mutations in the mevalonate kinases gene on chromosome 12. Most cases of HIDS have been reported from the Netherlands and surrounding European countries. It is likely that HIDS is underdiagnosed in the United States.

MeSH terms

  • Child
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / etiology*
  • Familial Mediterranean Fever / genetics
  • Humans
  • Hypergammaglobulinemia / complications*
  • Hypergammaglobulinemia / diagnosis
  • Hypergammaglobulinemia / genetics
  • Immunoglobulin D / blood
  • Infant
  • Male
  • Mutation*
  • Phosphotransferases (Alcohol Group Acceptor) / genetics*

Substances

  • Immunoglobulin D
  • Phosphotransferases (Alcohol Group Acceptor)
  • mevalonate kinase