Abstract
CCR1 is a CC chemokine receptor with high affinity for RANTES (regulated upon activation, normal T cells expressed and secreted). CCR1 protein and mRNA concentrations in native peritoneal cells were twofold greater, in cultured peritoneal cells threefold greater, in patients with endometriosis compared to patients without endometriosis, as determined by Western blotting fluorescence activated cell sorting analysis, reverse transcription-polymerase chain reaction, and in situ hybridization.
Publication types
-
Comparative Study
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Analysis of Variance
-
Cells, Cultured
-
Endometriosis / genetics
-
Endometriosis / metabolism*
-
Female
-
Flow Cytometry
-
Gene Expression Regulation / physiology
-
Humans
-
In Situ Hybridization
-
Macrophages, Peritoneal / metabolism*
-
Receptors, CCR1
-
Receptors, Chemokine / biosynthesis*
-
Receptors, Chemokine / genetics
-
Receptors, Chemokine / physiology
-
Reverse Transcriptase Polymerase Chain Reaction
-
Statistics, Nonparametric
Substances
-
CCR1 protein, human
-
Receptors, CCR1
-
Receptors, Chemokine