Abstract
C-Mpl and PRV-1 expression was measured in a cohort of 48 patients with essential thrombocythemia (ET). A retrospective analysis was conducted to asses whether the presence of one or both markers correlates with a higher risk of developing thromboembolic complications. In this cohort, PRV-1 overexpression was associated with a significantly increased risk of thrombosis, whereas decreased c-Mpl expression was not. The results of this retrospective analysis must now be corroborated in a large, prospective trial of newly diagnosed patients.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Female
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GPI-Linked Proteins
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Hemorrhage / complications
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Hemorrhage / metabolism*
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Humans
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Isoantigens / biosynthesis*
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Male
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Membrane Glycoproteins / biosynthesis*
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Middle Aged
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Proto-Oncogene Proteins / biosynthesis*
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RNA, Messenger / metabolism
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Receptors, Cell Surface / biosynthesis*
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Receptors, Cytokine / biosynthesis*
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Receptors, Thrombopoietin
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Retrospective Studies
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Risk
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Thrombocythemia, Essential / complications*
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Thrombocythemia, Essential / metabolism*
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Thrombosis / complications
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Thrombosis / metabolism*
Substances
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CD177 protein, human
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GPI-Linked Proteins
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Isoantigens
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Membrane Glycoproteins
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Proto-Oncogene Proteins
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RNA, Messenger
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Receptors, Cell Surface
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Receptors, Cytokine
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Receptors, Thrombopoietin
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MPL protein, human