Abstract
We report the case of a 58-year old patient, showing a solid image in the right kidney, who underwent radical nephrectomy that revealed neoplasia, whose pathological study led to the diagnosis of kidney carcinoma associated with Xp11.2 translocation / TFE3 (ASPL-TFE3) gene fusion. The authors discuss aspects related to this lesion, such as frequency, pathogenesis, clinical presentation, histopathology and outcome, as observed in the literature.
MeSH terms
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Carcinoma, Renal Cell / genetics*
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Carcinoma, Renal Cell / pathology
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Chromosomes, Human, X / genetics*
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DNA-Binding Proteins / genetics*
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Female
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Humans
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Kidney Neoplasms / genetics*
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Kidney Neoplasms / pathology
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Middle Aged
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Transcription Factors / genetics*
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Translocation, Genetic / genetics*
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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TFE3 protein, human
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Transcription Factors